The Rosie Project by Graeme Simsion is a book you will read at one sitting. Even if you start it at 10PM, you will read it at one sitting, starting in the armchair, moving to the bathtub and ending up in bed, not once putting down the book until you've turned the very last page.
Is it a romance? Yes.
Is it humorous? Very.
Is it original? You have no idea.
I'll quickly sketch the setup, so you can rush out and buy the book. Figuratively speaking, of course. I know you'll probably just click your Kindle button.
The protagonist, an undiagnosed Asperger's and a professor of genetics, is embarking on a project: Find A Wife. She should:
be a great cook
eat everything, including offal
not wear makeup
With a premise like that, you just know he's going to get the complete opposite, don' t you?